CIEN Showcases Nine Studies at AAIC 2026

A strong delegation of researchers from the CIEN Foundation (Foundation for the Research Centre for Neurological Diseases) will travel to London in the coming hours to participate in the Alzheimer's Association International Conference (AAIC) 2026, the world's leading scientific meeting dedicated to Alzheimer's disease and other dementias. The CIEN delegation will take part in the Preconference on 11 July, followed by the main scientific conference, which will be held from 12 to 15 July.

During the meeting, researchers from the Reina Sofía Alzheimer Center–CIEN Foundation will present nine scientific studies addressing some of the major challenges in neurodegenerative disease research, ranging from the identification of novel biomarkers for early diagnosis to the development of advanced neuroimaging techniques capable of tracking disease progression and improving disease characterization.

Developed in collaboration with leading institutions in Spain, Sweden, the United Kingdom and the United States, these studies highlight CIEN's growing international profile and reinforce the role of the Reina Sofía Alzheimer Center as one of Europe's leading centres for translational research in Alzheimer's disease and related dementias.

The research presented spans a broad range of topics, including cerebral amyloid angiopathy, plasma biomarkers such as p-tau217, quantitative magnetic resonance imaging, brain PET imaging, proteomics, patterns of brain atrophy, and innovative approaches to better understand the progression of Alzheimer's disease and other related neurodegenerative disorders.

In addition, one of the studies led by CIEN researchers has been selected for an oral presentation, a distinction reserved for research of particular scientific significance within the AAIC 2026 scientific programme.

Participation in AAIC 2026 further demonstrates CIEN's commitment to research excellence and to translating scientific discoveries into clinical practice, with the ultimate goal of enabling earlier and more accurate diagnosis while contributing to the development of future therapeutic strategies.

CIEN Scientific Programme at AAIC 2026

11 July

• AIC #261 | 07:30–16:15
  Atrophy patterns underlying progression to cognitive decline in individuals with low and high plasma p-tau217 levels
  Presenter: Cristina Sánchez-Martín.
• AIC #12223 | 07:30–16:15
  FDG-PET and structural MRI signatures of imaging-defined advanced primary age-related tauopathy mimicking early-stage AD
  Presenter: Jesús Silva-Rodríguez.
• AIC #12485
  Differential sensitivities of MRI and FDG-PET for tracking tau-related neurodegeneration in Alzheimer's disease using in-vivo tau-PET
  Presenter: Orfeas Vourkas.
• AIC #12338 | 12:05–13:15 and 15:00–16:00
  Long-term longitudinal patterns of hypometabolism and atrophy progression from preclinical to dementia stages of Alzheimer's disease
  Presenter: Miguel A. Labrador-Espinosa.
• AIC | 12:05–13:15 and 15:00–16:00
  Tau pathology associates with increased perfusion asymmetry in the medial temporal lobes independent of cognitive impairment
  Presenter: Linda Zhang.
• AIC #110 | 15:00–16:00
  Serial ante-mortem MRI analysis of regional atrophy progression in autopsy-confirmed LATE-NC with hippocampal sclerosis
  Presenter: Andrés Jiménez Pérez.

12 July

• AAIC #0092 | 07:30–16:15
  Atrophy patterns underlying progression to cognitive decline in individuals with low and high plasma p-tau217 levels
  Presenter: Cristina Sánchez-Martín.
• AAIC #9591 | 07:30–16:15
  Perivascular spaces reflect neuropathological severity of Cerebral Amyloid Angiopathy in Alzheimer's disease
  Presenter: Mario Ricciardi Serra.
• AAIC | 07:30–16:15
  Proteomic Signatures of Cognitive Decline and Resilience by %p-tau217 Status
  Presenter: Aitana Sogorb-Esteve. First author: Sonia Wagner-Reguero.
• AAIC | 10:30–11:00, 12:15–14:00 and 15:30–16:15
  Tau pathology associates with increased perfusion asymmetry in the medial temporal lobes independent of cognitive impairment
  Presenter: Linda Zhang.
• AAIC #4694 | 10:30–11:00, 12:15–14:00 and 15:30–16:15
  Long-term longitudinal patterns of hypometabolism and atrophy progression from preclinical to dementia stages of Alzheimer's disease
  Presenter: Miguel A. Labrador-Espinosa.

14 July

• Oral Presentation | 08:00–08:45
  Session 3-05-LPR – Multimodal Neuroimaging: Microstructure, Atrophy, and Machine Learning
  Room N11A
  Serial ante-mortem MRI analysis of regional atrophy progression in autopsy-confirmed LATE-NC with hippocampal sclerosis
  Presenter: Andrés Jiménez Pérez.

15 July

• AAIC #3004 | 07:30–16:15
  FDG-PET and structural MRI signatures of imaging-defined advanced primary age-related tauopathy mimicking early-stage AD
  Presenter: Jesús Silva-Rodríguez.
• AAIC #6901 | 07:30–16:15
  Differential sensitivities of MRI and FDG-PET for tracking tau-related neurodegeneration in Alzheimer's disease using in-vivo tau-PET
  Presenter: Orfeas Vourkas.
• AAIC #12688 | 07:30–16:15
  Associations of Cortical QSM-Derived Paramagnetic and Diamagnetic Signals with CSF Biomarkers of Alzheimer's Disease
  Presenter: Marina Fernández-Álvarez.