CIEN Research Team Actively Participates in the International AAIC 2025 Conference in Toronto
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A prominent representation of the team from the Centro de Investigación de Enfermedades Neurológicas (CIEN) is participating in the Alzheimer’s Association International Conference (AAIC) 2025. This conference, one of the world’s leading forums in the field of Alzheimer’s disease and other dementias research, will be held this year from July 26 to 29 in Toronto, Canada.
During the conference, researchers from CIEN’s Clinical and Neuroimaging Platforms will present ten scientific contributions, including poster presentations and one oral presentation, focused on key advances in plasma biomarkers, neuroimaging, and neuropathological findings in the context of cognitive decline and neurodegenerative diseases.
Among the most notable contributions is the oral presentation by Dr. J. Michel Grothe, titled “The MRI signature of LATE-NC-associated hippocampal sclerosis extends beyond the medial temporal lobe.”
The posters cover a wide range of topics, including:
- Longitudinal changes in cognitively unimpaired individuals with elevated plasma ptau-217 levels
- Comparisons between FDG-PET and MRI in the early detection of neurodegenerative changes
- The role of glial biomarkers (GFAP) in cognitive decline
- Neuropathological evaluation of the Boston Criteria v2.0 for cerebral amyloid angiopathy
- The impact of dream recall on biomarkers and cognition
The contributions will be presented by Linda Zhang, Elizabeth Valeriano-Lorenzo, and Michel J. Grothe, highlighting the center’s multidisciplinary and international collaboration.
CIEN’s participation in AAIC 2025 reflects its commitment to cutting-edge, translational research and strengthens its presence on the international stage in the study of neurodegenerative diseases.
CIEN Contributions to AAIC 2025
| Presentation Title | Lead Author | Type | Date | Code |
|---|---|---|---|---|
| Baseline and long-term longitudinal atrophy patterns of cognitively unimpaired individuals with elevated plasma ptau-217 | Cristina Sánchez-Martín | Póster | Saturday, July 26 / Tuesday, July 29 | AIC-050 / Tuesday-465 |
| FDG-PET Outperforms MRI in Monitoring Early Neurodegenerative Changes Tied to Neurofibrillary Tangle Pathology: An Imaging-Pathology Study | Orfeas Vourkas | Póster | Saturday, July 26 / Monday, July 28 | AIC-131 / Monday-458 |
| Increased cortical mean diffusivity in cognitively unimpaired individuals with elevated plasma ptau217 | Linda Zhang | Póster | Saturday, July 26 / Tuesday, July 29 | AIC-164 / Tuesday-453 |
| The MRI signature of LATE-NC-associated hippocampal sclerosis extends beyond the medial temporal lobe | J. Michel Grothe | Oral (Featured Research Session)/Póster | Sunday, July 27 (4:15–5:45 PM) / Saturday, July 26 | 1-32-FRS-A / AIC-321 |
| Long-term trajectories of cognition, neurodegeneration, and clinical progression in cognitively unimpaired individuals with elevated plasma p-tau217 | Jesús Silva-Rodríguez | Póster | Monday, July 28 | Monday-902 |
| Long-term cognitive and biomarker trajectories of cognitively unimpaired individuals with different levels of plasma ptau-217 | Jesús Silva-Rodríguez | Póster | Sunday, July 27 | Sunday-314 |
| Modulatory effect of GFAP on the association between plasma p-tau217 levels and cognitive decline in older adults | Elisabeth Lucía Valeriano-Lorenzo | Póster | Tuesday, July 29 | Tuesday-334 |
| Dream recall in cognitively healthy older adults: associations with blood p-tau217, APOE ε4, and cognitive decline | D. M. Lipnicki | Póster | - | - |
| Neuropathological evaluation of the Boston Criteria v2.0 for cerebral amyloid angiopathy in Alzheimer's disease dementia | Mario Ricciardi | Póster | Monday, July 28 (7:30 AM – 4:15 PM) | - |