Page 19 - Memora anual Fundación CIEN 2015

1. PROFILE AND PRESENTATION
visits have been submitted to the CIEN Foundation
Scientific Advisory Committee and members of the
Queen Sofia Foundation. In addition to presenting
our preliminary results in different conferences and
scientific meetings during 2015 the first description of these diseases, when presented alone or, more
the Vallecas project has been published in an inter-
national scientific journal (see Section 6 of this re-
port). The project is generating great interest among
the scientific community and we look forward to
presenting our results in national and international
conferences and publishing scientific papers of the
first longitudinal analysis throughout 2016.
As the project progresses it is producing a number of
increasingly richer and more relevant information
about the earliest stages of cognitive impairment in
subjects that progress to that state, as well as the
most suitable biomarkers (clinical, biochemical and
neuroimaging) to characterize and identify the po-
pulation at increased risk of developing it.
In the coming months we will initiate the necessary
contacts so that information obtained from assess-
ments of the volunteers, their biological samples and
neuroimaging studies undertaken could integrate
with other national and international cohorts, which
significantly will increase the potential of each one
of them and the Vallecas project itself.
In addition to the Vallecas project, the Alzheimer
project will continue to be an essential project for
the Queen Sofia Foundation Alzheimer Center and
CIEN Foundation and a growing source of informa-
tion (clinical, molecular, neuroradiological and neu-
ropathological) on mild and severe dementia
stages. This longitudinal study, initaited in 2007, aims
to monitor residents at the Queen Sofia Foundation
Alzheimer Centre and users of the Day Center.
In the coming months and years the information ga-
thered since the beginning of the project will provide
important clues on how the two main pathologies
that lead to dementia in our environment, the Alz-
heimer's and cerebrovascular disease, interact and
result in defined progression pathways. A better un-
derstanding of the various forms of expression of
commonly, in combination, will allow to approach
in depth their role in the origin of dementia and to
identify patient groups who require special care or
that can benefit from specific therapies.
The research model implemented in the Alzheimer
Center can be equally applied to other residences
and other Day centers around the Region of Madrid.
In fact, the Alzheimer Project model in other social
health environments is being put into in Day Centers
from the Associations of Relatives of Alzheimer pa-
tients (AFA) in Soria, León, and other towns, in order
to incorporated subjects diagnosed with mild cog-
nitive impairment and mild dementia in future Foun-
dation projects.
Moreover, a new study (the Madrid+CIEN project)
has been designed in collaboration with the Region
of Madrid General Directorate for the Elder and the
European University, aimed at establishing a cohort
of hundred-year-old subjects in our Region. The pro-
ject aims at establishing the cognitive profile of cen-
tenarians who have no dementia, studying cognitive
profile progression over a period of three years and
establishing a cohort of centenarians in which would
be possible to set up studies with non-pharmacolo-
gical therapies.
CIEN Foundation Annual Report 2015 / 19